MMP14 Fluorogenic Assay Kit
The Fluorogenic MMP14 Assay Kit is designed to measure MMP14 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
Need us to run inhibitor screens or profile your compounds against MMP14? Check out our Protease Screening Services.
Fluorescent microplate reader capable of reading λexc/λem=328 nm/393 nm
| Catalog Number |
Component |
Amount |
Storage |
|
| 100585 | MMP14, His-tag | 7 µg | -80°C | Avoid freeze/ thaw cycles! |
| 79919 | Fluorogenic MMP Substrate (1 mM) | 10 µl | -80°C | |
| 79917 | 1X MMP Assay Buffer 1 | 25 ml | -20°C | |
| 79685 | Black, low binding black microtiter plate | 1 | Room Temp |
|
MMP14 (matrix metalloproteinase 14) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix.MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) degradation and remodeling, cell invasion, and cancer metastasis. MMP14 is highly expressed in most sarcomas, and levels of MMP14 correlate with breast cancer progression. Upregulation of MMP14 also promotes glioma invasion and tumor cell proliferation and plays a role in angiogenesis.
1. Chun, Tae-Hwa, et al. 2010. "Genetic link between obesity and MMP14-dependent adipogenic collagen turnover." Diabetes 59(10): 2484-2494.
2. Chen, Tzy-Yen, et al. 2011. "Role of MMP14 gene polymorphisms in susceptibility and pathological development to hepatocellular carcinoma." Annals of Surgical Oncology 18(8): 2348-2356.
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