CD47 - HEK293 Cell Line
Catalog #
71249
$6,950
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Purchase
Description
Recombinant HEK293 cell line over-expressing full length human CD47 (NM_198793.2). Surface expression is confirmed by flow cytometry.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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Synonyms
Rh-associated protein, GP42, integrin-associated protein (IAP), neurophilin
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Product Data Gallery
Expression of CD47 protein in CD47/HEK293 cells validated by Western blot and flow cytometry
Product Info
Storage and Usage
Citations
Host Cell Line
Human Embryonic Kidney cell line (HEK293). Adherent epithelial cells.
Format
Each vial contains ~3 x 10^6 cells in 1 ml of 10% DMSO in FBS.
UniProt #
Q08722
Background
CD47 (also known as Rh-associated protein, GP42, integrin-associated protein (IAP), and neurophilin,) is an immunoglobulin-like protein that interacts with its receptor, Signal-regulatory protein alpha (SIRPα), on macrophages. This binding interaction regulates transmigration, oxidative burst cytokine production, and phagocytosis, creating a “don’t eat me” signal. CD47 is ubiquitously expressed on the surface of normal cells, but is overexpressed in numerous cancer cells, where it is thought to contribute to the resistance of tumors to phagocyte-dependent clearance.
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Products are for Research Use Only
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