CD4, Fc Fusion, Avi-Tag Recombinant
Recombinant human CD4, encompassing amino acids 26-396, corresponding to the extracellular domain. This construct includes an Fc-domain from human IgG1 fused at the C-terminus, followed by an Avi-tag™. This protein was affinity purified.
≥90%
Aqueous buffer solution.
8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
CD4 (cluster of differentiation 4) is part of the immunoglobulin superfamily and is found in T-helper cells, monocytes, macrophages, and dendritic cells. It is a co-receptor in the TCR (T cell receptor), binding to MHC (major histocompatibility complex) class II molecules. CD4 binds to the tyrosine kinase Lck (lymphocyte-specific protein tyrosine kinase), which phosphorylates the ITAM (immunoreceptor tyrosine activation motifs) domain of the CD3, activating CD3-related signaling. CD4 is a typical T cell marker of T helper cells. It has been linked to cancer, autoimmune diseases such as vitiligo, and type I diabetes. In addition, HIV-1 uses CD4 as a receptor to trigger viral envelope protein conformational changes that allow cell infection. Ibalizumab, an anti-CD4 antibody, is currently used in the treatment of HIV, being considered a first-in-class medication. Further studies into CD4 and potential strategies around it may benefit patients and CD4 related diseases.
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