OX40 Signaling and Its Implications for Immunotherapy
Introduction
Immune checkpoint OX40, also known as CD134 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. Its significance in regulating immune responses has garnered substantial attention in the field of immunotherapy. OX40 signaling plays a crucial role in modulating T cell activation, differentiation, and survival, thereby influencing the outcome of immune responses agains...
OX40 & OX40L Research Products
The OX40:OX40L pathway is a critical co-stimulatory system that modulates T cell activation, differentiation, and survival.
Immune checkpoint OX40, also known as CD134 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. OX40 is mainly expressed by activated CD4 + and CD8 + T cells and is transiently induced upon TCR stimulation. T...
Methods For Drug Discovery
Immunotherapies based on targeting the PD-1:PD-L1 immune checkpoint pathway are having clinical impact and are giving new hope to cancer patients. However, positive response to treatment is not guaranteed and resistance remains a concern. Improving outcomes based on immunotherapy requires multiple approaches for manipulating the complexities of the immune system and tumor microenvironment. To meet these challenges, a series of r...
Citations
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