NAMPT: Metabolism, Cancer, and Drug Discovery
NAMPT & Metabolism
The unique metabolic requirements of rapidly reproducing cells are classical targets for cancer treatment. For example, rapid growth creates a high demand for ATP used in the biosynthesis of DNA and proteins. The enzymatic cofactors NAD + and NADH contribute oxidizing and reducing agents required to generate ATP and regulate the resulting oxidative stress. This need for high levels of A...
Nicotinamide Adenine Dinucleotide
Overview
NAD+ plays an important role as a cofactor in enzyme catalyzing redox reactions by transferring electrons to/from its reduced form, NADH. It also serves as a substrate for various enzymes such as Sirtuins , Poly ADP-ribose polymerases (PARPs), and CD38 .
Clinical Importance
Recent studies revealed that cellular NAD+ concentration is associated with chronological aging and age-related diseases, suggesting it is important to un...
Metabolic Enzyme Screening & Profiling
Metabolic enzymes that regulate cellular energy pathways are essential for life. This includes all the processes required for material circulation and energy exchange, including catabolism and anabolism of nucleotides, sugars, proteins, and lipids. Metabolic pathway abnormalities have been correlated with diseases, such as diabetes and cancer, and are under investigation for targeted therapeutics.
We ...
Methyl-lysine Reader Screening & Profiling
Methyl-lysine reader proteins specifically recognize methylated lysine on histone tails and help to convey this epigenetic modification by recruiting activating or repressive factors regulating downstream processes such as cell cycle regulation, stress responses, development processes, or oncogenesis. Their involvement in cancer makes them attractive therapeutic targets.
We offer a selection of scr...
Immunotherapy Biochemical Screening Services
Immunotherapy is a type of medical treatment that engages the body's immune system to fight diseases, such as cancer, infections, and autoimmune disorders. It works by either stimulating the immune system to attack cancer cells or other disease-causing agents, or by using synthetic proteins or antibodies to target specific molecules on the surface of cancer cells or other pathogens. Immunotherapy has shown prom...
