Mechanism of JAK-STAT Signaling in Cancer
Cell Signaling Pathways
Understanding cell to cell communication through cytokines and other secreted factors is at the center of daily life for countless pharmaceutical researchers. This is because cytokine-based communication is central to normal development and is often a dysfunctional step in cancer and autoimmune diseases ( 1, 2 ). It is also of increasing importance because cytokine release syndrome is a leading caus...
The Promise of NK Cell Therapeutics
Introduction
NK cells are the first line of defense against cancer and have been in the spotlight as a cancer therapy in the last decade. Their advantages versus T cells, such as their safety profile and not requiring MHC (Major Histocompatibility Complex)-antigen stimulation to become cytotoxic, have made NK cells attractive. However, as with T cells, the TME (tumor microenvironment) can suppress their activity, and infiltration into solid tumors is s...
