Nicotinamide Adenine Dinucleotide
Overview
NAD+ plays an important role as a cofactor in enzyme catalyzing redox reactions by transferring electrons to/from its reduced form, NADH. It also serves as a substrate for various enzymes such as Sirtuins , Poly ADP-ribose polymerases (PARPs), and CD38 .
Clinical Importance
Recent studies revealed that cellular NAD+ concentration is associated with chronological aging and age-related diseases, suggesting it is important to un...
HDAC/Sirtuin Screening & Profiling
Histone deacetylases (HDACs) are negative regulators of gene transcription due to their ability to tightly compact heterochromatin by removing acetyl groups from histone tails. Thus, they are considered important targets for anti-cancer therapeutics due to their involvement in cell cycle regulation, cell proliferation, and apoptosis, and overall gene expression. Similarly, the Sirtuin family of deacetylases are targets ac...
NAMPT: Metabolism, Cancer, and Drug Discovery
NAMPT & Metabolism
The unique metabolic requirements of rapidly reproducing cells are classical targets for cancer treatment. For example, rapid growth creates a high demand for ATP used in the biosynthesis of DNA and proteins. The enzymatic cofactors NAD + and NADH contribute oxidizing and reducing agents required to generate ATP and regulate the resulting oxidative stress. This need for high levels of A...
Custom Biochemical Assay Development
BPS Bioscience has the capability to develop robust biochemical assays using our portfolio of assay technologies. Our biochemical assay development services enable you to generate an appropriate assay which is suitable for screening and evaluating your target of interest. Our cross-functional team of scientists can also work closely with you to develop assays for compound library screening as well as for secondary screening support. ...
Acetyltransferase Screening & Profiling
The transfer of acetyl groups to lysine residues of histone proteins by acetyltransferase enzymes is critical to epigenetic control of genes in cell maintenance and survival. Histone acetyltransferases (HATs) are involved in disease processes as well and have garnered attention as targets for therapy across a number of pathological areas including cancer, neurodegenerative disorders, and inflammatory diseases.
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Screening and Profiling Services
Evaluate lead compounds with our biochemical and cell-based screening services to identify specific inhibitors or activators. Save time by letting us screen your small molecules or biologics of interest against our unique assay panels or determine IC 50 values. With our portfolio of > 600 assays available as a service, we’re here to help advance your drug discovery program.
Our biochemical-based inhibitor...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
