SHP-2 Activating Peptide (IRS1_pY1172(dPEG8)pY1222)
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Catalog #
79319
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Description
IRS1_pY1172(dPEG8)pY1222(SEQ: H2N-LN(pY)IDLDLV(dPEG8)LST(pY) -ASINFQK-amide)
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Product Info
Storage and Usage
Citations
Purity
>95% (by HPLC)
Concentration
100 µM
Background
It has been shown that the bisphosphorylated insulin receptor substrate 1 (IRS-1) binds to the (N)-SH2 domain of SHP-2 (PTPN11) resulting in activation of the SHP-2 enzymatic activity.
References
Chen Y-N et. al., Nature, 535(7610):148-152 (2016)
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