SHP-2 (PTPN11), GST-tag Recombinant
Catalog #
30022
$325
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Description
Protein tyrosine phosphatase SHP-2, also known as PTPN11 (GenBank accession number NM_002834), a.a. 224-529 (catalytic domain) with N-terminal GST-tag, MW=62 kDa, expressed in an E. coli expression system.
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Synonyms
SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433, SHP
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Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione.
MW
62 kDa
Amino Acids
224–529
Specific Activity
>1,000 pmol/min/µg
Genbank #
NM_002834
UniProt #
Q06124
Background
Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
References
1. B.G. Neel et al. Trends Biochem. Sci. (2003) 28:284.
2. J.V. Ravetch and L.L. Lanier Science (2000) 290:84.
3. S. Yamazaki et al. J. Infect. Dis. (2003) 187:334.
2. J.V. Ravetch and L.L. Lanier Science (2000) 290:84.
3. S. Yamazaki et al. J. Infect. Dis. (2003) 187:334.