AURORA C, GST-tag Recombinant

Catalog #

40178

$410 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human Aurora C, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

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Synonyms

AURKC, AIE2, AIK3, AurC, STK13, aurora-C

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

61 kDa

Amino Acids

full length

Genbank #

NM_003160

UniProt #

Q9UQB9

Tag(s)

N-terminal GST-tag

Background

Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).

References

1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595.
2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397.

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AURORA C, GST-tag Recombinant

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