Yes1, GST-tag Recombinant
Catalog #
40488
$385
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Description
Human, full length, YES1, also known as Yes, c-yes, HsT441, P61-YES GenBank Accession No. NM_005433, with N-terminal GST tag, a.a. 2- 543(end), MW 88 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
This product has been cited 4 times.
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Synonyms
Yes, c-yes, HsT441, P61-YES
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Product Info
Storage and Usage
Citations4
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥70%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110
mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 3
mM DTT, and 20% glycerol.
MW
91 kDa
Amino Acids
full length
Specific Activity
200 pmole/min/µg
Genbank #
NM_005433
UniProt #
P07947
Background
YES1 is the cellular homolog of the Yamaguchi sarcoma virus oncogene that has tyrosine kinase activity and belongs to the SRC family. YES1 lies in close proximity to thymidylate synthase gene on chromosome 18 and chromosome 22 (1). The activation of YES1 may play a significant role in the malignant transformation of hepatocytes, and is important for maintaining embryonic stem cells in an undifferentiated state. YES1 is a useful marker to detect early-stage hepatocellular carcinoma, and it plays a key role in the tumorigenesis and metastasis of gastric cancer. YES1 induction results in increased cancer cell motility suggesting that YES1 may promote cancer spread and metastasis rather than tumor growth (2).
References
1. Silverman, G. et.al, Genomics 15: 442-445, 1993.
2. Barraclough, J. et al, Neoplasia. 2007 Sep;9(9):745-54.