TNFR2 HEK293 Cell Line

Catalog #

78828

$7,150 *

Size: 2 vials

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

Recombinant HEK293 cell line constitutively expressing human TNFR2 gene (TNFRSF1B or CD120b, NM_001066.3) under the control of the CMV promoter.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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Synonyms

TNFRSF1B, TNFBR, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2 (TNF-R2), Tumor necrosis factor receptor type II (TNF-RII; TNFR-II), p75, p80 TNF-alpha receptor, CD120b, TBP-2, TBPII, Etanercept

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Product Data Gallery

Expression of TNFR2 in TNFR2 HEK293 Cell Line

Product Info

Storage and Usage

Citations

Host Cell Line

HEK293, Human Embryonic Kidney, epithelial-like cells, adherent

Supplied As

Each vial contains 2 x 10⁶ cells in 1 ml of Cell Freezing Medium (BPS Bioscience #79796)

Materials Required But Not Supplied

Name	Ordering Information
Thaw Medium 1	BPS Bioscience #60187
Growth Medium 1N	BPS Bioscience #79801

UniProt #

P20333

Mycoplasma Testing

The cell line has been screened to confirm the absence of Mycoplasma species.

Background

Tumor Necrosis Factor Receptor 2 (TNFR2, also known as TNFRSF1B or CD120b) is a transmembrane receptor of the TNF protein superfamily that binds the pleiotropic pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). TNFR2 can be found in several T-Cell subsets such as regulatory CD8⁺ T-Cells (Tregs) and CD4⁺ tumor-infiltrating T cells, myeloid lineage cells and some cancer types, and it is involved in autoimmune diseases, graft versus host disease and cancer. It has become an attractive target for cancer immunotherapy, where its different functions as oncogene and immune regulator are being explored. TNFR2 also exhibits neuroprotective properties and promotes tissue regeneration, making it a promising potential therapeutic target for the treatment of Alzheimer’s disease.

Storage/Stability

Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Growth Media

For best results, the use of validated and optimized media by BPS Bioscience is highly recommended. Other preparations or formulations of media may result in suboptimal performance.

Thaw Medium 1 (BPS Bioscience #60187): MEM medium supplemented with 10% FBS, 1% non-essential amino acids, 1 mM Na pyruvate, 1% Penicillin/Streptomycin.

Growth Medium 1N (BPS Bioscience #79801): MEM medium supplemented with 10% FBS, 1% non-essential amino acids, 1 mM Na pyruvate, 1% Penicillin/Streptomycin plus 0.5 µg/mL Puromycin.

Applications

Screen and characterize TNFR2 antibodies.
Study TNFR2 signaling in HEK293 cells.

Shipping Temperature

-80°C

Notes

License Disclosure
Visit bpsbioscience.com/license for the label license and other key information about this product.

Troubleshooting Guide
Visit bpsbioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email [email protected].

Warnings

Avoid freeze/thaw cycles

Scientific Category

Cell Signaling Pathway

Regulatory Status

Research Use Only