Temsirolimus

Catalog #

27024

$125 *

Size: 10 mg

Qty

Bulk/Custom

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Description

Temsirolimus, a rapamycin (sirolimus) derivative, also known as CCI-779, is an mTOR inhibitor with anti-cancer activity. Temsirolimus down-regulated the mTOR signaling intermediate phospho-S6 in xenografted human ALL. Temsirolimus has been shown to reverse cisplatin resistance in small cell lung cancer cell lines selected for cisplatin resistance and in cell lines derived from patients who failed cisplatin therapy.

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Synonyms

CCI-779, Torisel

Product Info

Storage and Usage

Citations

Purity

≥99%

Format

White to off-white solid.

Formula

C₅₆H₈₇NO₁₆

1030.3 Da

Solubility

Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

CAS Registry #

162635-04-3

References

1. Wan, X., et al. Neoplasia 8: 394-401 (2006).
2. Teachey, D.T., et al. Blood 107: 1149-1155 (2006).
3. Wu, C., et al. Mol. Cancer 4: 25-34 (2005).

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Temsirolimus

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