MMP3 Fluorogenic (K45E) Assay Kit
The MMP3 (K45E) Inhibitor Screening Assay Kit is designed to measure the endopeptidase activity of MMP3 (K45E) for screening and profiling applications.
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Adjustable micropipettor and sterile tips
Fluorescent microplate reader
| Catalog Number |
Component |
Amount |
Storage |
|
| 11346 | MMP3 (K45E) | 50 µg | -80 °C | Avoid muliplte freeze/ thaw cycles! |
| AMPA (100 mM) | 10 µg | -20 °C | ||
| MMP3 substrate (6 mM) | 20 µg | -20 °C | ||
| 4X MMP3 buffer | 10 ml | -20 °C | ||
| 384-well black microplate | 1 | Room Termp |
||
Matrix metalloproteinase 3 (MMP3) is a zinc-dependent endopeptidase involved in the breakdown of extracellular matrix and tissue remodeling in normal physiological processes, such as embryonic development and reproduction, as well as in disease processes, such as arthritis and cancer. Overexpression of MMPs is associated with tumor invasion, neoangiogenesis and metastasis. Several inhibitors of MMPs (MMPI), small molecules and blocking monoclonal antibodies, have entered clinical trials. MMP3 (K45E) variant is associated with differences in MMP3 activity and has been linked to cancer susceptibility.
Nagase, H., et al. Biochemistry. 1990. 29(24): 5783-5789.
Mendes, O., et al. Clin Exp Metastasis. 2005. 22(3): 237-246.
Dormán, et al. Drugs. 2010. 70(8): 949-964.
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