KHS1 (GCKR), GST-tag Recombinant

Catalog #

40115

$410 *

Size: 10 µg

Qty

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Description

Recombinant human KHS1, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.

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Synonyms

MAP4K5, KHS, GCKR, MAPKKKK5

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

Sf9 insect cells

Purity

≥75%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.

135 kDa

Amino Acids

full length

Genbank #

NM_006575

UniProt #

Q9Y4K4

Tag(s)

N-terminal GST-tag

Background

KHS1 belongs to serine/threonine kinase family that has a STE20-like protein kinase domain which stimulates the stress-activated protein kinase (SAPK, also known as Jun kinase or JNK) pathway (1). It is a mitogen-activated protein kinase kinase kinase kinase 5, termed germinal center kinase related (GCKR). Recently, the KH domain of Escherichia coli polynucleotide phosphorylase has been reported to be necessary for autoregulation and growth at low temperature (2).

References

1. Shi, C.S. et al: TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. J. Immunol. 1999;163(6):3279-85.
2. Maura Epifania, M.O. et al: The KH and S1 domains of Escherichia coli polynucleotide phosphorylase are necessary for autoregulation and growth at low temperature. Biochim. et Biophy. Acta (BBA). 2007; 1769 (3):194-203

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KHS1 (GCKR), GST-tag Recombinant

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