IL-2RB, Avi-His-Tag Recombinant
Recombinant human IL-2RB (Interleukin-2 receptor subunit beta), encompassing amino acids 27-239. This construct contains a C-terminal Avi-Tag™ followed by a His-tag (6xHis). The recombinant protein was affinity purified
≥90%
Interleukin-2 (IL-2) is a cytokine secreted by activated T lymphocytes to stimulate the proliferation of both B and T cells. IL-2 is involved in the extreme inflammation response termed “cytokine storm” observed following viral infection in susceptible patients or following adaptive cell therapy. Thus, it is considered a therapeutic target for the treatment of severe COVID-19. IL-2 acts by binding to a membrane heterotrimeric receptor consisting of IL-2 receptor alpha (IL2RA, also known as CD25) and beta (IL2RB, also known as CD122) chains, which together with the common gamma chain (IL2RG) form a high-affinity receptor, whereas IL-2RA homodimers form a low-affinity receptor. Polymorphisms in the genes coding for IL2RA and IL2RB may be associated with risk of lung cancer.
1. Cavanillas, M., et al. 2010. Eu. J. Human Genetics. 18:794-799.
2. Parsian, A., et al. 2002. Am. J. Med. Gen. 74(4):361-364.
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