ICOS (CD278), Fc fusion (Human) Recombinant

Catalog #

71179

$320 *

Size: 100 µg

Qty

Bulk/Custom

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Description

Human ICOS, Fc fusion protein, also known as inducible T-cell costimulator and CD antigen 278, activation-inducible lymphocyte immunomediatory molecule, AILIM, CD278, and CVID1. GenBank Accession No. NM_012092, a.a. 21-140 expressed in a HEK293 cell expression system. MW = 40.2 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.

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Synonyms

Inducible T-cell costimulator and CD antigen 278, activation-inducible lymphocyte immunomediatory molecule, AILIM, CD278, CVID1

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

HEK293

Purity

≥90%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

40.2 kDa

Endotoxin Level

<1 EU/µg

Amino Acids

21-140

Genbank #

NM_012092

UniProt #

Q9Y6W8

Tag(s)

C-terminal Fc fusion (Human IgG1)

References

1. Hutloff, A. et al., Nature. 1999; 397: 263- 266.
2. Dong, C. et al., Nature. 2001; 409: 97- 101.

Storage/Stability

At least 6 months at –80°C.

Instructions for Use

Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.

Applications

Useful for studying protein binding and for screening small molecules and antibodies.

Shipping Temperature

-80°C

Notes

The aggregation state of this product has been confirmed to be <10%.

Warnings

Avoid freeze/thaw cycles. Protein may be diluted to ≥ 100 μg/ml in PBS + glycerol and stored at -80°C.

Scientific Category

Immunotherapy

Regulatory Status

Research Use Only

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Datasheets/Protocols

71179_Lot140722-D.pdf

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ICOS (CD278), Fc fusion (Human) Recombinant

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