Human Thymic stromal lymphopoietin Recombinant
Catalog #
90250-B
$205
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Description
Recombinant human TSLP is a protein consisting of Tyr29-Gln159 amino acid residue subunits, due to glycosylation migrates as an approximately 25 kDa protein under reducing conditions in SDS-PAGE. DNA sequence encoding Human TSLP mature chain was expressed in HEK293 cells.
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Synonyms
TSLP, Thymic stromal lymphopoietin
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Product Data Gallery
TSLP Activity (Representative data only; data may vary lot by lot.)
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
HEK293
Purity
≥95% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered 1 mg/ml solution of 20 mM phosphate buffer, pH 7.4, 150 mM NaCl.
MW
Due to glycosylation migrates as an approximately 25 kDa protein on SDS-PAGE
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
29–159
Biological Activity
The activity as determined by binding Human TSLPR in an ELISA assay.
UniProt #
Q969D9
Background
Thymic stromal lymphopoietin (TSLP) promotes the growth and activation of B cells. It also has wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4?, CD8? and natural killer T cells, and epithelial cells. TSLP plays a role in the promotion of TH2 responses in lung- and skin-specific allergic disorders, and it also is involved in the blockade of TH1/TH17 responses and the promotion of cancer and autoimmunity.
References
1. Ziegler SF, et al. Adv Pharmacol. 2013,66:129-55.
2. Yu X, et al. Cell Immunol. 2012 Oct,279(2):174-9.
3. Roan F, et al. J Leukoc Biol. 2012 Jun,91(6):877-86.
2. Yu X, et al. Cell Immunol. 2012 Oct,279(2):174-9.
3. Roan F, et al. J Leukoc Biol. 2012 Jun,91(6):877-86.
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