Anti-TSLP Neutralizing Antibody

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Catalog #
102138
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Description

 This anti-TSLP (thymic stromal lymphopoietin) neutralizing antibody is a purified, recombinant monoclonal antibody that recognizes human TSLP. This antibody has been tested for specific binding to purified recombinant TSLP.

Synonyms
thymic stromal lymphopoietin, TSLP
Product Info
Storage and Usage
Citations
Species
Human
Isotype
IgG2
Clonality
Monoclonal
Host Species/Expression System
HEK293
Purity

≥90%

Format

Aqueous buffer solution.

Formulation

8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

MW
Heavy Chain: 50 kDa + glycans; Light Chain: 23 kDa
Glycosylation
This antibody runs at a higher MW by SDS-PAGE due to glycosylation.
UniProt #
Q969D9
Background

TSLP (thymic stromal lymphopoietin) is a protein that functions as a type I cytokine, as an alarmin and growth factor in the immune system. It is involved in type 2 immune responses, TH2 (T helper 2 cells) responses, and the maturation and recruitment of dendritic cells (DCs), T cells, B cells, neutrophils, mast cells, and other lymphoid cells.  It can be produced by epithelial and stromal cells in lung, skin, and gastric system, but also by DCs, basophils and mast cells. Its expression can be induced by infections, pro-inflammatory cytokines, proteases, and even mechanical injury. For instance, it can be produced in the lungs in response to infection with influenza or rhinovirus. Its role as alarmin can result in increasing inflammation. TSLP is linked to allergic reactions, such as asthma, atopic dermatitis, and food allergies, by inducing the expression of OX40L, CD80 and CD86 and stimulating CD4+ T cells. In 2021, the TLSP-neutralizing antibody tezepelumab was approved for the treatment of severe asthma. Targeting TSLP is an active area of investigation with ongoing clinical trials for the treatment of autoimmune disorders.