EIF2AK3, GST-tag Recombinant

Catalog #

40059

$410 *

Size: 10 µg

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Description

Recombinant human EIF2AK3 (a.a. 563-1115), with N-terminal GST-tag, expressed in E. coli cells

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Synonyms

PERK, PEK, WRS, HRI, DKFZp781H1925, double-stranded RNA-activated protein kinase

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution

Formulation

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

115 kDa

Amino Acids

563–1115

Genbank #

NM_004836

UniProt #

Q9NZJ5

Tag(s)

N-terminal GST-tag

Background

EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation and a rapid reduction of translational initiation and repression of global protein synthesis. EIF2AK3 is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins (1). EIF2AK3 plays a major role in the ability of cells to adapt to ER stress and is also involved in an integrated adaptive response to hypoxic stress in HeLa cells (2). EIF2AK3 functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia.

References

1. Harding, H. P. et.al: EIF2AK3 is essential for translational regulation and cell survival during the unfolded protein response. Molec. Cell 5: 897-904, 2000.
2. Blais, J. D. et.al: Activating transcription factor 4 is translationally regulated by hypoxic stress. Molec. Cell. Biol. 24: 7469-7482, 2004.

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EIF2AK3, GST-tag Recombinant

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