Claudin-1 CHO Cell Line
CHO cell line stably expressing human Claudin-1 (NM_021101.5). Surface expression of Claudin-1 was confirmed by flow cytometry. The stable clonal cell line was selected for its high levels of Claudin-1 expression compared to the parental CHO-K1 cell line.
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| Name | Ordering Information |
| Thaw Medium 3 | BPS Bioscience #60186 |
| Growth Medium 3J | BPS Bioscience #79974 |
The cell line has been screened to confirm the absence of Mycoplasma species.
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. They are also involved in cell growth and differentiation. Often, several claudin family members are co-expressed and interact with each other, and this determines the overall cell permeability. Claudin-1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. It is involved in normal water homeostasis and prevention excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since Claudin-1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. The expression levels and localization of claudins relate to the ability of tumors to invade and to their aggressive characteristics. Claudin 1 is one of the most studied claudins in the context of cancer, but its precise roles are still unclear. Further studies into its roles will provide new cancer therapy options.
Bhat A., et al., 2020, Int J Mol Sci 21(2):569.
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