CK2a1, GST-tag Recombinant
Catalog #
40045
$410
*
●
●
Purchase
Description
Human CK2α1, also known as CK2alpha1, CSNK2A1 and CKII, GenBank Accession No. NM_001895, a.a. full length, with an N-terminal GST-tag, expressed in an Sf9 infected baculovirus expression system. MW=70 kDa.
●
Synonyms
CSNK2A1, CKII
●
Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥85%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
MW
70 kDa
Amino Acids
full length
Specific Activity
91 pmol/min/µg
Genbank #
NM_001895
UniProt #
P68400
Background
CK2α is a serine-threonine protein kinase whose targets include many critical regulators of cellular growth. It is highly expressed in a lymphopro-liferative disease of cattle and in many human cancers. Overexpression of the CK2 catalytic subunit in lymphocytes of transgenic mice leads to T cell lymphoma (1). The highest CK2α1 activity is found in mouse testicles and brain, followed by spleen, liver, lung, kidney and heart (2).
References
1. Rifkin, IR. et al. J Immunol. 1998 Nov 15,161(10):5164-70.
2. Guerra B. et al. FEBS Lett. 1999 Dec 3,462(3):353-7
3. 462(3):353-7