CHIR-99021 (CT99021) HCl
Catalog #
27615-3
$650
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Description
CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor which can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β).
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Synonyms
CHIR-99021; CT99021; 6-((2-((4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile hydrochloride
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
98%
Supplied As
Solid
Target(s)
PI3K/Akt/mTOR Signaling
Formula
C22H18Cl2N8 •HCl
MW
501.8
Solubility
≥25.1 mg/ml in DMSO; ≥4.23 mg/ml in H2O; ≥4.83 mg/ml in EtOH. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.
CAS Registry #
1797989-42-4
References
1. Ring et al (2003). Diabetes 52 588.
2. Pan et al (2011). Neuropsychopharmacology 36 1397.
3. Ye et al (2012). PLoS One 7 e35892.
2. Pan et al (2011). Neuropsychopharmacology 36 1397.
3. Ye et al (2012). PLoS One 7 e35892.
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