CHIR-99021 (CT99021)
Catalog #
27614-2
$295
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Description
CHIR-99021 is a highly specific glycogen synthase kinase-3 (GSK-3) inhibitor which can inhibit both isoforms with IC50 of 10 nM (GSK-3α) and 6.7 nM (GSK-3β).
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Synonyms
CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile
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Product Data Gallery
Chemical Structure
Product Info
Storage and Usage
Citations
Purity
≥97%
Format
Solid
Target(s)
GSK-3
Formula
C22H18Cl2N8
MW
465.34 Da
Solubility
≥23.27 mg/ml in DMSO; insoluble in EtOH; insoluble in H2O. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.
CAS Registry #
252917-06-9
References
1. Ring et al (2003). Diabetes 52 588.
2. Pan et al (2011). Neuropsychopharmacology 36 1397.
3. Ye et al (2012). PLoS One 7 e35892.
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