SARS-CoV-2 Antibody Detection
SARS-CoV-2 has spread across the globe effectively at a rapid pace causing a worldwide pandemic. Infection with this highly contagious respiratory virus can be asymptomatic or present as COVID-19, a disease with varying degrees of severity. Clinical symptoms may include fever, dry cough, anosmia, gastrointestinal symptoms, hypercoagulability, hyperimmune response (cytokine storm), and acute respiratory distress syndrome (ARDS) with disease progression (1). Patie...
SARS-CoV-2 Variants: Evading the Immune System
The COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus , has ravaged the globe, infecting over 145 million people and causing over 3 million deaths as of the time of this article. Ending the pandemic will require a combination of effective interventions, including therapeutics, diagnostics, and vaccines. Several monoclonal antibody therapeutics have received emergency use authorization, and a number of vaccines have been devel...
Lentiviruses for SARS-CoV-2 Research
To understand the mechanism of SARS-CoV-2 cell entry, it is essential to study how Spike proteins interact with the ACE2 receptor. However, such studies are hampered by the danger of producing and manipulating live coronavirus. A safer alternative to using live coronavirus is to use recombinant lentivirus pseudotyped with the coronavirus S protein. The Spike pseudotyped lentivirus includes a luciferase reporter, allowing the monitoring of viral entry into...
SARS-CoV-2 Coronavirus & COVID-19
There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).
The S...
Coronavirus Services
Biochemical Screening
Cell-Based Services
Cell Lines /CRISPR
Protein Binding Studies/BLI
BPS Bioscience has developed innovative proteins , cell lines , lentiviruses , and assay kits , to enable a wide range of preclinical activities for investigating potential COVID-19 antiviral drugs. These kits and services aim to rapidly advance drugs into the clinic by screening for compounds that prevent the ...
Frequently Asked Questions
BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.
Proteins
Cell Lines
Assay Kits ...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
VSV Tools
VSV (Vesicular stomatitis virus) is an enveloped, negative-stranded RNA virus with a simple structure. Its ability to infect a wide range of mammalian cell types has made VSV a valuable tool to study virus entry, replication, and assembly. The glycoprotein of VSV (termed VSV-G), which binds to the LDL-receptor (low-density lipoprotein receptor), is responsible for the attachment and entry of VSV into a susceptible host cell.
The VSV-G glycoprotein can be deleted from the VSV (V...
Proteases as Targets for SARS-CoV-2 Treatment
Researchers have shown that proteases are actively used by SARS-CoV-2 for it’s entry and replication into human cells. To support research on this topic, BPS Bioscience provides a range of screening kits to identify inhibitory compounds directed against these human and viral proteases.
SARS-CoV-2’s mechanism of entry and replication into human cells is now well known and described by the scientific community. The penetration steps can be d...
SARS-CoV-2 Accessory Proteins & ORF9b
Coronavirus SARS-CoV-2 is an enveloped virus that interacts with host cells via a protruding protein called Spike , and fuses with the cellular membrane to inject its genome into the cell. The SARS family of coronaviruses contain a large single stranded RNA genome of about 30 kb with both unique and conserved features compared to other coronaviruses [1].
The presence of a 5′ methylated cap and a 3′ poly-adenylated tail allows the posit...
Custom Lentivirus Services
BPS Bioscience has developed a diverse portfolio of lentivirus products to study COVID-19 , cell signaling pathways , CAR T-cell therapy , CRISPR , and immunotherapy . In addition to our product portfolio , we also offer custom services to develop a lentivirus suited for your research needs.
Customizable Options
Reporters ( GFP , Luciferase , Dual Reporter )
Antibiotic selection markers ( Puromycin , Hygromycin , G4...
