HVEM, LIGHT & BTLA: New Immunotherapy Target
The checkpoint receptors HVEM , LIGHT , CD160 , and BTLA are part of a complex network of overlapping receptor interactions that function in both immune stimulation and suppression 1 , 2 . This regulatory function has made them therapeutic targets for treatment of cancer, autoimmune diseases and allergies, and for improved methods of organ transplants. While presenting opportunities for...
Combining Therapies for Targeting Immune Checkpoints
| IMMUNE CHECKPOINTS | | KINASES | | PARPS | | HDACS | | CAR T-CELL THERAPY |
Cancer is a balance between the defens...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
Siglecs & Immunotherapy
BPS has released a number of Siglec proteins and stable cell lines for studying immune-oncology and immune regulation .
Cells of the immune system express a multitude of complex glycans on their surfaces, making them highly recognizable by diverse glycan-binding proteins. Siglecs (Sialic-acid-binding immunoglobulin-like lectins) are type I transmembrane proteins that bind to glycans containing sialic acid. These highly polymorphic proteins have very dist...
Emerging Therapeutic Approaches Against RAS Cancer Mutations
Introduction
RAS (rat sarcoma virus) proteins are small GTPases involved in signal transduction as part of the RAS/MAPK (mitogen-activated protein kinase) pathway and are involved in cell proliferation and differentiation. There are three human RAS genes: KRAS (Kristen rat sarcoma virus), HRAS (Harvey rat sarcoma virus) and NRAS (neuroblastoma rat sarcoma virus). The KRAS gene encodes two isoforms, KRAS-4B and KRAS-4A, but due t...
Protein Tyrosine Phosphatase Screening & Profiling
Protein tyrosine phosphatases (PTPs) are enzymes that dephosphorylate proteins with a phosphate group on tyrosine residues, counteracting the effects of protein kinases and providing a mechanism for tightly controlled regulation of signaling processes related to cell proliferation, metabolism, motility, synaptic plasticity, and survival. Altered expression or function of PTPs have been implicated in human...
