OX40 Signaling and Its Implications for Immunotherapy
Introduction
Immune checkpoint OX40, also known as CD134 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. Its significance in regulating immune responses has garnered substantial attention in the field of immunotherapy. OX40 signaling plays a crucial role in modulating T cell activation, differentiation, and survival, thereby influencing the outcome of immune responses agains...
OX40 & OX40L Research Products
The OX40:OX40L pathway is a critical co-stimulatory system that modulates T cell activation, differentiation, and survival.
Immune checkpoint OX40, also known as CD134 or TNFRSF4, is a co-stimulatory molecule belonging to the tumor necrosis factor receptor (TNFR) superfamily. OX40 is mainly expressed by activated CD4 + and CD8 + T cells and is transiently induced upon TCR stimulation. T...
Combining Therapies for Targeting Immune Checkpoints
| IMMUNE CHECKPOINTS | | KINASES | | PARPS | | HDACS | | CAR T-CELL THERAPY |
Cancer is a balance between the defens...
