IDO/TDO Pathway
BPS Bioscience is a trusted provider and manufacturer of IDO pathway reagents, assay kits, cell lines and services. Cancer cells use the indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) pathways to suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells. IDO enzymes and IDO-related enzymes are active in many tumors, providing a direct defense against T cell attack. I...
IDO/TDO Screening Services
BPS offers biochemical and cell-based IDO/TDO screening services which can effectively accelerate your research and drug discovery programs. With all screening and profiling services, we provide a comprehensive (>10 page) report with both raw and analyzed data, graphs, detailed protocols, etc. Trust us to provide you with high quality data with fast turnaround time. Our team of experts along with our broad services portfolio makes it easy...
Immunotherapy Biochemical Screening Services
Immunotherapy is a type of medical treatment that engages the body's immune system to fight diseases, such as cancer, infections, and autoimmune disorders. It works by either stimulating the immune system to attack cancer cells or other disease-causing agents, or by using synthetic proteins or antibodies to target specific molecules on the surface of cancer cells or other pathogens. Immunotherapy has shown prom...
COX1 & COX2 Screening Services
Prostanoids are signaling molecules which mediate inflammation and vasoconstriction. These signaling molecules are formed through the action of cyclooxygenase (COX) enzymes. Two COX isoforms exist, COX1 and COX2. COX1 helps to produce mucus lining for the stomach and is also expressed in a variety of other tissue types. Meanwhile, COX2 expression is generally restricted to inflamed cells and works to upregulate prostanoid levels.
COX enzyme...
Metabolic Enzyme Screening & Profiling
Metabolic enzymes that regulate cellular energy pathways are essential for life. This includes all the processes required for material circulation and energy exchange, including catabolism and anabolism of nucleotides, sugars, proteins, and lipids. Metabolic pathway abnormalities have been correlated with diseases, such as diabetes and cancer, and are under investigation for targeted therapeutics.
We ...
Immunotherapy Cell-Based Screening Services
Development of immunotherapies is becoming more prevalent for treatment of diseases, such as cancer, infections, and autoimmune disorders. While biochemical assays can clearly identify inhibitors of protein-protein interactions or protein activity, cell-based assays can provide additional insight in the context of live cells.
We offer rapid and dependable cell-based assay screening services to find compounds...
The Promise of NK Cell Therapeutics
Introduction
NK cells are the first line of defense against cancer and have been in the spotlight as a cancer therapy in the last decade. Their advantages versus T cells, such as their safety profile and not requiring MHC (Major Histocompatibility Complex)-antigen stimulation to become cytotoxic, have made NK cells attractive. However, as with T cells, the TME (tumor microenvironment) can suppress their activity, and infiltration into solid tumors is s...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
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10X HAT Assay Buffer (50095...
