Search results for: 'car lentivirus'

Custom CAR-T Cell Development CAR-T cell therapy is a revolutionary cancer treatment that involves genetically engineering immune cells, using either the patient’s own cells or allogeneic cells, to recognize and attack cancer cells using a Chimeric Antigen Receptor (CAR). This therapy has shown remarkable success in treating some types of blood cancers, such as leukemia and lymphoma, even in patients who have not responded to other treatments. While CAR-...

CAR-T Cell Therapy Engineering T cells using a chimeric antigen receptor (CAR) to boost specific immune cell killing has made significant progress in the treatment of some cancer types. CAR-T cell therapy may also have potential benefits beyond cancer treatment, including treatments for infectious and chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR-T cell therapy in organ transplantation to eliminate the n...

Custom Lentivirus Services BPS Bioscience has developed a diverse portfolio of lentivirus products to study COVID-19 , cell signaling pathways , CAR T-cell therapy , CRISPR , and immunotherapy . In addition to our product portfolio , we also offer custom services to develop a lentivirus suited for your research needs.  Customizable Options Reporters ( GFP , Luciferase , Dual Reporter ) Antibiotic selection markers ( Puromycin , Hygromycin , G4...

Lentiviruses Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering. It has recently made its way to the clinic with ex-vivo cell therapy applications. Lentiviruses (LV) have also been used extensively for the modeling of SARS-CoV-2 viral infection of human cells. Lentiviral transduction is a powerful tool for introducing genes into cells and is used extensively for cellular engineering...

The Power of Lentiviruses in Cell Engineering Introduction The ability to manipulate nucleic acids has been a key discovery that has driven research, and ultimately clinical applications, forward. It opened the door to study the impact of mutations in cellular models, dissect pathways, generate recombinant proteins and monoclonal antibodies, and is the basis of gene and cell therapy, continuing to lead to new discoveries and cure patients every day. The methods used to ...

CD19 Research Products CD19, a cell surface protein specific to B cells, has emerged as an effective immunotherapy target to treat B cell malignancies and autoimmune diseases. By leveraging monoclonal antibodies, chimeric antigen receptor (CAR) T cells and NK cells, or bispecific T cell/NK cell engagers (BiTEs/BiKEs), CD19-directed immunotherapies aim to selectively eliminate CD19-expressing cells. In cancer, these ther...

CAR-T Cell Therapy Engineering T cells using a chimeric antigen receptor (CAR) to boost specific immune cell killing has made significant progress in the treatment of some cancer types. CAR-T cell therapy may also have potential benefits beyond cancer treatment, including treatments for infectious and chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR-T cell therapy in organ transplantation to eliminate the n...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...

Virus-Based Tools Virus-based tools such as Lentivirus, Adeno-Associated Virus (AAV), and Vesicular Stomatitis Virus (VSV) are critical for cell engineering and the study of viral infection.  We have designed a suite of ready-to-use viral reagents to address a wide span of research areas including virology (particularly Coronaviruses), immunotherapy, CAR-T therapy, CRISPR, cell signaling, and more.        Lentiviruses Ideal for pseudotyp...

Gene & Cell Therapy Gene and cell therapies are paving the way for innovative treatments that can offer new hope for patients with previously untreatable diseases. Gene therapy and cell therapy are cutting-edge medical approaches aimed at revolutionizing healthcare. Gene therapy involves the manipulation and introduction of genetic material into a patient's cells to correct genetic disorders or enhance therapeutic effects. This can be achieved by ...

Adoptive Cell Therapy Using Antigen-Specific TCRs Engineered T cell receptors provide a promising therapeutic approach to fight cancer by focusing immune cells to target specific antigens. Antigen-specific T-cell receptors (TCRs) play a crucial role in the adaptive immune response by recognizing specific antigen peptides presented by MHC molecules on the surface of infected or abnormal cells. These TCRs are typically found on the surface ...

Bioluminescent Cells for Cell Line-Derived Xenograft (CDX) Models Cell line-derived xenograft (CDX) models are important in vivo models that serve to determine anti-tumor efficacy, pharmacokinetics/pharmacodynamics, toxicity, and other characteristics of drug candidates. They can be used effectively across a range of therapeutic modalities, including small molecules, antibodies, and CAR-T, among others. BPS Bioscience has specifically engineered human-derived cell lines constitutively expr...

SARS-CoV-2 Coronavirus & COVID-19 There are seven known human coronaviruses , including the novel SARS-CoV-2. Four of these strains cause only mild respiratory symptoms; however, coronaviruses became notorious after outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. The SARS-CoV-2 (2019-nCoV) coronavirus, first identified in late 2019, causes severe pneumonia and respiratory infection (COVID-19).  The S...

...

Claudin-18: A Therapeutic Target in Oncology Claudins, a family of small tetraspan proteins expressed in a tissue or cell-specific manner, are major components of the multimeric protein architecture of tight junctions, which prevent ions or small molecules from passing freely between epithelial or endothelial cells. These proteins contain four transmembrane domains mainly responsible for interacting side-to-side with neighboring proteins. Two extracellular loops regulate p...

Frequently Asked Questions BPS Bioscience is here to answer your questions and provide project guidance. On the following pages, we outline some of the most frequently asked questions separated by product type. If your question is not answered through these resources, please contact us today and we are happy to assist.  Proteins Cell Lines Assay Kits ...

Conferences & Events Development of a Cell-Based Reporter Assay for Measuring ADAR1 Editing Activity for Drug Discovery and Cell Biology Research May 21, 2024 (8:00 AM PT, 11 AM ET) Adenosine Deaminase Acting on RNA (ADAR) enzymes perform adenosine to inosine base editing in RNA, particularly targeting adenosines located within a specific double-stranded stem-loop motif.  ADAR1 plays important roles in inflammation, autoimmune diseases, and cancer, and represents ...

Technical Notes and Application Notes Immunotherapy | Cancer Targets | CAR-T/NK Cell Therapy | Gene & Cell Therapy | Cell Culture | RNA Editing | Cancer Pathways | CRISPR/Cas9 | Cell Receptor Targets | Ubiquitination | Protein Conjugation | Technology | Cholesterol Pathways | SARS-CoV-2/COVID-19 Immunotherapy TL1A:DR3 - A Pathway for Immunomodulation Therapeutic Targeting of TSLP in Asthma and COPD A2aR & Im...

Natural Killer Cells Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cell therapies. Natural Killer (NK) cells are lymphocytes involved in the innate immune system that respond to infected cells and tumor cells, limiting these pathologies. They are now considered potential tools for adoptive cel...

Primary Cells To support innovation across Immunology and other research areas, BPS Bioscience offers negatively selected, highly enriched CD4+ and CD8+ T cells, and ready-to-use Chimeric Antigen Receptor (CAR)-T cells such as anti-CD19 CAR, anti-BCMA CAR, and control T cells. Primary CAR-T cells, produced by high-titer lentiviral transduction of human primary CD4+ and CD8+ T cells, are used as a positive control in CAR-T cytotoxicity assays, in the design...

Cell Isolation Kits Our cell isolation kits allow for fast, simple, and efficient isolation of specific immune cell subsets. Optimized for the isolation of cells from normal human peripheral blood mononuclear cells (PBMCs), our kits use magnetic bead: antibody complexes to separate target antigen-expressing cells from heterogeneous cell populations. For positive selection kits, cells are incubated with the antibody:bead complexes and then p...

Cell-Based Assays and Expression Kits Cells can be engineered to serve as readouts for cell-based assays as a complement or alternative to biochemical assays. A variety of cell-based assay types can be used for research and development applications, including signaling pathway analysis, inhibitor/activator studies, CAR-T cell functional screening, ADCC assays, high-throughput screening systems and much more. We provide a variety of cell-based assay express...

ADC and Antibody-Based Cancer Therapies Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers. Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers. Monoclonal antibodies, which are laboratory-produced molecules that bind to a specif...

Siglecs & Immunotherapy BPS has released a number of Siglec proteins and stable cell lines for studying immune-oncology and immune regulation . Cells of the immune system express a multitude of complex glycans on their surfaces, making them highly recognizable by diverse glycan-binding proteins. Siglecs (Sialic-acid-binding immunoglobulin-like lectins) are type I transmembrane proteins that bind to glycans containing sialic acid. These highly polymorphic proteins have very dist...