Cell Cytotoxicity Screening & Profiling Services
Small Molecule Cell Cytotoxicity Assays
Understanding cell cytotoxicity, either as a result of targeted therapy or as a side effect, is important in drug development. Our expert scientists can help determine effective dose curves for your molecules of interest in whole cell assays, whether they are small molecules or biologics, including antibody drug conjugates. Over 30 different tumor cell lines are availabl...
CAR T-Cell Therapy
Overview
CAR-T is a cross of immunotherapy, gene therapy, and cellular therapy. Many successful immunotherapies are based on checkpoint inhibitors that block the mechanisms tumor cells use to hide from T cells. CAR-T immunotherapies go one step further by engineering T cells to enhance the immune response against a specific tumor antigen. CAR-T is a promising approach for cancer and other diseases, especially severe cancers that do not respond well to othe...
CRISPR-Based Synergistic Activation Mediator (SAM)
Introduction
Cas9 ( Streptococcus pyogenes CRISPR-associated protein 9) is a sequence-specific prokaryotic endonuclease that is recruited to the DNA by a single guide RNA (sgRNA) and introduces a double stranded break into the DNA. This double stranded break is usually repaired through Non-Homologous End Joining (NHEJ) in mammalian cells (1) . The target DNA sequence requires only 23 bp (base pairs) in length and sho...
