Search results for: 'BCMA'

Targeting BCMA in Mutliple Myeloma Multiple Myeloma Multiple myeloma is the second most commonly diagnosed blood cancer, after non-Hodgkin lymphoma. Multiple myeloma is a cancer in which immortalized plasma cells accumulate in the bone marrow, causing severe pain, anemia, and kidney failure. Multiple myeloma was once considered universally fatal. Improved diagnostic methods and innovative treatments are improving patient outcomes. Still, nearly all patients eventually relapse a...

BAFF:BCMA Assay Service

CAR T-Cell Therapy Overview CAR-T is a cross of immunotherapy, gene therapy, and cellular therapy. Many successful immunotherapies are based on checkpoint inhibitors that block the mechanisms tumor cells use to hide from T cells. CAR-T immunotherapies go one step further by engineering T cells to enhance the immune response against a specific tumor antigen. CAR-T is a promising approach for cancer and other diseases, especially severe cancers that do not respond well to othe...

CAR-T Cell Therapy Engineering T cells using a chimeric antigen receptor (CAR) to boost specific immune cell killing has made significant progress in the treatment of some cancer types. CAR-T cell therapy may also have potential benefits beyond cancer treatment, including treatments for infectious and chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR-T cell therapy in organ transplantation to eliminate the n...

CAR-T Cell Therapy Engineering T cells using a chimeric antigen receptor (CAR) to boost specific immune cell killing has made significant progress in the treatment of some cancer types. CAR-T cell therapy may also have potential benefits beyond cancer treatment, including treatments for infectious and chronic inflammatory diseases such as hepatitis, HIV/AIDS, lupus, and arthritis. Companies are also investigating CAR-T cell therapy in organ transplantation to eliminate the n...

Primary Cells To support innovation across Immunology and other research areas, BPS Bioscience offers negatively selected, highly enriched CD4+ and CD8+ T cells, and ready-to-use Chimeric Antigen Receptor (CAR)-T cells such as anti-CD19 CAR, anti-BCMA CAR, and control T cells. Primary CAR-T cells, produced by high-titer lentiviral transduction of human primary CD4+ and CD8+ T cells, are used as a positive control in CAR-T cytotoxicity assays, in the design...

Technical Notes and Application Notes Immunotherapy | Cancer Targets | CAR-T/NK Cell Therapy | Gene & Cell Therapy | Cell Culture | Cancer Pathways | CRISPR/Cas9 | Cell Receptor Targets | Ubiquitination | Protein Conjugation | Technology | Cholesterol Pathways | SARS-CoV-2/COVID-19 Immunotherapy A2aR & Immunotherapy BCMA & Cancer Bispecific Antibodies Combination Therapies for Targetin...

ADC and Antibody-Based Cancer Therapies Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers. Antibody-based therapies, such as antibody-drug conjugates (ADCs) and multi-specific T cell engager molecules, provide a targeted approach to treating cancers. Monoclonal antibodies, which are laboratory-produced molecules that bind to a specif...

Cell Cytotoxicity Screening & Profiling Services Small Molecule Cell Cytotoxicity Assays Understanding cell cytotoxicity, either as a result of targeted therapy or as a side effect, is important in drug development. Our expert scientists can help determine effective dose curves for your molecules of interest in whole cell assays, whether they are small molecules or biologics, including antibody drug conjugates. Over 30 different tumor cell lines are availabl...

Citations   This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.  Search By Product Name or Catalog Number Name Title 10X HAT Assay Buffer (50095...

Immunotherapy Biochemical Screening Services Immunotherapy is a type of medical treatment that engages the body's immune system to fight diseases, such as cancer, infections, and autoimmune disorders. It works by either stimulating the immune system to attack cancer cells or other disease-causing agents, or by using synthetic proteins or antibodies to target specific molecules on the surface of cancer cells or other pathogens. Immunotherapy has shown prom...