HDAC/Sirtuin Screening & Profiling
Histone deacetylases (HDACs) are negative regulators of gene transcription due to their ability to tightly compact heterochromatin by removing acetyl groups from histone tails. Thus, they are considered important targets for anti-cancer therapeutics due to their involvement in cell cycle regulation, cell proliferation, and apoptosis, and overall gene expression. Similarly, the Sirtuin family of deacetylases are targets ac...
Citations
This page contains a list of scientific journal articles that have cited BPS products and services since 2013. We would like to congratulate all our loyal customers on their contributions to the scientific community. Our customers are truly amazing and dedicated scientists and this is evidenced by the outstanding research they are doing.
Search By Product Name or Catalog Number
Name
Title
10X HAT Assay Buffer (50095...
NAMPT: Metabolism, Cancer, and Drug Discovery
NAMPT & Metabolism
The unique metabolic requirements of rapidly reproducing cells are classical targets for cancer treatment. For example, rapid growth creates a high demand for ATP used in the biosynthesis of DNA and proteins. The enzymatic cofactors NAD + and NADH contribute oxidizing and reducing agents required to generate ATP and regulate the resulting oxidative stress. This need for high levels of A...
Combining Therapies for Targeting Immune Checkpoints
| IMMUNE CHECKPOINTS | | KINASES | | PARPS | | HDACS | | CAR T-CELL THERAPY |
Cancer is a balance between the defens...
Screening and Profiling Services
Evaluate lead compounds with our biochemical and cell-based screening services to identify specific inhibitors or activators. Save time by letting us screen your small molecules or biologics of interest against our unique assay panels or determine IC 50 values. With our portfolio of > 600 assays available as a service, we’re here to help advance your drug discovery program.
Our biochemical-based inhibitor...
