Caspase6, His-tag Recombinant

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Catalog #

80113

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Description

Human Caspase 6 (CASP6), full length encompassing amino acids 1-293 (end). This construct contains a C-terminal His-tag (6xHis). The recombinant protein was affinity purified. Pro-caspase-6 is activated by autocleavage to yield 20 kDa and 18 kDa proteins (large subunits) and an 11 kDa small subunit that multimerize to form the active enzyme.

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Synonyms

Caspase-6, CASP6, Caspase 6, Mch2, Caspase

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Product Data Gallery

4-20% SDS-PAGE Coomassie staining

Caspase 6 Activity

Caspase-6 inhibition curve using a fluorogenic assay (#80703). Representative data only; data may vary by lot.

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 320 mM imidazole, 0.01% Tween-20, and 20% glycerol.

See Description

Amino Acids

1–293 (end)

Specific Activity

≥ 1720 pmol/min/µg

Genbank #

NM_001226

UniProt #

P55212

Tag(s)

C-terminal His-tag

Background

Caspase 6 is cysteine-aspartic acid protease that plays a central role in the execution of apoptosis (programmed cell death) as part of a sequential caspase activation cascade. Caspase 6 is processed and activated by caspases 7, 8, and 10. One of the main functions of caspase 6 is to cleave cytoskeletal proteins, such as lamin A and fodrin, leading to cytoskeletal disruption and cell shrinkage to facilitate the breakdown of the cellular architecture involved in membrane blebbing and nuclear condensation that are characteristic of apoptosis. It also cleaves proteins involved in DNA repair and RNA processing. Caspase 6 has been implicated in neurodegenerative diseases such as Alzheimer's disease and may be involved in the abnormal accumulation of misfolded amyloid-beta. It has also been shown to cleave neuron protein Tau.

References

1. Halawani, D., et al., J Neurosci. 2010 Apr 28;30(17):6132-42.
2. LeBlanc, A., et al., J Biol Chem. 1999 Aug 13;274(33):23426-36.

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Datasheets/Protocols

80113_Lot130222-2.pdf

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Caspase6, His-tag Recombinant

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