Activated Protein C (PROC) Assay Kit
The Activated Protein C (APC, also known as PROC) Assay Kit is a 96-well format fluorogenic assay designed to measure the protease activity of Activated Protein C (PROC) for screening and profiling applications.
Illustration of the assay principle.
The substrate is an internally quenched fluorogenic substrate. Proteolysis releases the highly fluorescent AMC. Fluorescence intensity increases proportionally to the activity of the protease.
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- Fluorescence plate reader capable of reading exc = 380 nm; em = 460 nm
- Adjustable micropipettor and sterile tips
- 30°C incubator
| Catalog # | Name | Amount | Storage |
| 70019 | Activated Protein C (PROC), His-Tag* | 13 µg | -80°C |
| PROC Assay Buffer | 5 ml | -20°C | |
| PROC Fluorogenic Substrate (20 mM) |
25 µl | -80°C | |
| 79685 | Black 96-well plate | 1 | Room Temp |
*The concentration of the protein is lot-specific and will be indicated on the tube.
Protein C, also known as autoprothrombin IIA and blood coagulation factor XIX, is a serine protease which acts as an anticoagulant and is normally expressed in its zymogen (pro-enzyme) form. Activated protein C (APC or PROC) inhibits coagulation by inactivating the proteolysis of Factor Va and Factor VIIIa and regulating blood vessel permeability and inflammatory responses. PROC activation is vitamin-K dependent and vitamin K deficiency or alterations in PROC activation can lead to increased risk of blood clot-related pathologies such as thrombosis.
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