Human Interleukin-6 Recombinant
Catalog #
90196-B
$205
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Description
Recombinant human Interleukin-6, also known as IL-6, is a disulfide-linked homodimeric protein consisting of 183 amino acids and migrates as an approximately 20 kDa protein under reducing conditions.
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Synonyms
il-6, Interleukin 6, CD126, IL6
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥97% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from a 0.2 µm filtered PBS solution, pH 7.0.
MW
20 kDa
Endotoxin Level
< 0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 7TD1 cells to be less than 0.1 ng/ml, corresponding to specific activity of 1x107IU/mg.
UniProt #
P05231
Background
IL-6 is a member of a family of cytokines, which also includes LIF, CNTF, Oncostatin M, IL11, and CT- 1. All known members of the IL-6 cytokine family induce hepatic expression of acute phase proteins. IL-6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. Macrophages, T-cells and B-lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells, and keratinocytes also produce IL-6 after stimulation. The IL-6 receptor is expressed on T-cells, mitogen-activated B-cells, peripheral monocytes and some macrophage- and B-cell derived tumor cell types. It is not expressed in resting B-cells but in resting T-cells. The IL-6 receptor (CD126) is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids.
References
1. Am. J. Respir. Cell Mol. Biol., Oct 2009, 41: 385 - 396.
2. Ann Rheum Dis, Oct 2009, 68: 1580 - 1584.
3. Glycobiology, Oct 2009, 19: 1082 - 1093.
2. Ann Rheum Dis, Oct 2009, 68: 1580 - 1584.
3. Glycobiology, Oct 2009, 19: 1082 - 1093.
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