USP11, His-Tag, FLAG-Tag Recombinant
Recombinant human USP11 (ubiquitin specific peptidase 11), encompassing amino acids 2-920. This construct contains a N-terminal His-tag (6xHis) and a C-terminal FLAG-tag. This protein was affinity purified.
≥80%
Aqueous buffer solution.
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 0.045% Tween-20, and 10% glycerol
USP1 (ubiquitin specific protease 11), or ubiquitin carboxyl-terminal hydrolase 11, belongs to the USP family of proteins. USP11 is a DUB (deubiquitinating enzymes) and is involved in removing K-48 and K-63 ubiquitin chains from several substrates. It participates in DNA repair and inflammation, can regulate immune cell differentiation via the NF-κB and TNF (tumor necrosis factor) pathways. It has been linked to the development and progression of several cancer types, such as breast, hepatocellular and ovarian cancer. The development of USP11 specific inhibitors will bring therapeutic benefits in cancer therapy.
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