TC-PTP(PTPN2), GST-Tag Recombinant
Catalog #
30013
$325
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Description
Human recombinant TC-PTP, also known as PTPN2 (protein tyrosine phosphatase N2), Genbank accession No. BC016727, a.a. 2-315 (catalytic domain), with N-terminal GST tag, MW=62.3 kDa, expressed in an E. coli expression system.
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Synonyms
PTPN2, TC-PTP, PTPT, TCELLPTP, TCPTP
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, and variable glutathione.
MW
62.3 kDa
Amino Acids
2–315
Specific Activity
1,000 pmole/min/µg
Unit Definition
One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C.
Genbank #
BC016727
UniProt #
P17706
Background
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.
References
1. N.F. Zander et al., Biochemistry 1991, 30: 6964.
2. D.E. Cool et al., Proc. Natl. Acad. Sci. USA 86: 5257.
2. D.E. Cool et al., Proc. Natl. Acad. Sci. USA 86: 5257.