STK33, GST-tag Recombinant
Catalog #
40093
$355
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Description
STK33 (GenBank Accession No. NM_030906.2), a.a. 2-end, with N-terminal GST-tag, MW = 84 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
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Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥46%
Format
Aqueous buffer solution
Formulation
45 mM Tris-HCl, pH 8.0, 115 mM NaCl, 10% glycerol, and 2 mM DTT.
MW
84 kDa
Amino Acids
2–end
Specific Activity
≥10 pmol/min/µg
Genbank #
NM_030906.2
UniProt #
Q9BYT3
Background
STK33 is a distant member of the CAMK group of serine/threonine kinases but it lacks the calcium/calmodulin-binding domain and the C-terminal regulatory tail. STK33 is highly expressed in testis, lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. STK33 is essential for abnormal cell growth in human cell lines expressing oncogenic mutations in KRAS, but not in human cancer cell lines expressing wildtype KRAS. STK33 is required for survival and proliferation of mutant KRAS-dependent cancer cells, in which it suppresses the S6K1-BAD proapoptotic signaling pathway.
References
1. Mujica, A.O., et al., 2001. Gene 280:175-181.
2. Brauksiepe, B., et al., 2008. Biochemistry 9:25-37.
2. Brauksiepe, B., et al., 2008. Biochemistry 9:25-37.