Sialidase, His-Tag Recombinant

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Catalog #

101734

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Description

Recombinant Salmonella typhimurium sialidase, also known as NANH (N-acylneuraminate glycohydrolase), full length encompassing amino acids 2-382. The construct contains an N-terminal His-tag (6xHis). This protein was affinity purified.

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Synonyms

Sialidase, N-acylneuraminate glycohydrolase, Neuraminidase (NANase), STNA, nanH, STM0928

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Sialidase inhibition curve using a fluorogenic assay (#82154). Representative data only; data may vary by lot.

Product Info

Storage and Usage

Citations

Species

Salmonella Typhimurium

Construct

Sialidase (His-2-382(end))

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution.

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol

43 kDa

Amino Acids

2-382(end)

Genbank #

AE006468.2

UniProt #

P29768

Tag(s)

N-terminal His-Tag

Background

Sialidases are glycosyl hydrolases that cleave the α-ketosidic bond from sialic acid residues. These proteins are crucial for microbes like Salmonella to successfully infect their hosts by degrading the cell’s glycans and contributing to adherence and infection. Salmonella typhimurium infection results in salmonellosis, characterized by gastrointestinal symptoms, such as abdominal cramps and diarrhea, which last from 4 to 7 days. It can, however, result in severe cases requiring hospitalization. Inhibitors targeting sialidases may prove useful in the treatment of bacterial infections.

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Datasheets/Protocols

101734 Lot 230801-1

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