PRAME Peptide (432-440)
The PRAME Peptide (432-440, GLSNLTHVL) is a peptide corresponding to PRAME (Preferentially Expressed Antigen in Melanoma), amino acids 432-440. The PRAME peptide is widely used to stimulate human PRAME-specific CD8+ T cells.
1 mM peptide in DMSO
PRAME (Preferentially Expressed Antigen in Melanoma) is a protein with a profile of expression in normal tissues highly restricted to testis, ovarium, and endometrium. However, it is found at high levels in several cancer types, such as melanoma, breast, and lung cancer. It is also found in cells of patients with AML (acute myeloid leukemia) and Hodgkin’s lymphoma. Overexpression seems to block retinoic acid (RA)-mediated cell proliferation, differentiation, and apoptosis, contributing to tumorigenesis. Its expression pattern makes it an attractive target for immunotherapy. It is a membrane-bound protein, and it is thus a good target for TCR (T cell receptor)-T cells and anti-PRAME vaccines. Several clinical trials are ongoing and have demonstrated the clinical potential of targeting PRAME in melanoma, lung cancer and other solid tumors. Further studies into the functions of this protein will bring new clinical advances in cancer therapy.
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