PEST (PTPN12), GST-tag Recombinant

Catalog #
30023
$325 *
Size: 50 µg
Qty
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Description

Human recombinant PTP-PEST, also known as PTPN12 (GenBank Accession #NM_002835), a.a. 2-300 (catalytic domain) with N-terminal GST tag, MW=61.4 kDa, expressed in an E. coli expression system.

Synonyms
PTP-PEST, PTPG1, tcag7.1075, PTPN12
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity

≥80%

Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione
MW
61.4 kDa
Amino Acids
2–300
Specific Activity
76 pmole/min/µg
Genbank #
NM_002835
UniProt #
Q05209
Tag(s)
N-terminal GST-tag
Background
Protein tyrosine phosphatase-PEST (PTPN12), a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, cell migration, and signal transduction for antigen receptors in B and T lymphocytes. Signal transduction via tyrosine phosphorylation, normally fine-tuned by the concerted action of both protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key mechanism in tumorigenesis. Studies suggest potential role for PTP-PEST in regulation of p130(cas) in mitogen- and cell adhesion-induced signaling events.
References
1. J.F. Cote, et al., J Biol Chem. 2002, 277: 2973-86.
2. K. Horsch et al., Mol Endocrinol. 2001, 12: 2182-96.