NSD3 (1021-1322) (WHSC1L1), GST-tag Recombinant

Catalog #

51036

$385 *

Size: 50 µg

Qty

Bulk/Custom

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Description

Recombinant humanNSD3 (nuclear receptor binding SET domain protein 3), encompassing amino acids 1021-1322. This construct contains an N-terminal GST-tag. A short peptide linker placed between GST and the protein includes a PreScission Protease Cleavage Site to facilitate removal of the GST portion. The recombinant protein was affinity purified.

This product has been cited 2 times.

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Synonyms

NSD-3, nuclear receptor binding SET domain protein-3, KMT3F, KMT3G, WHISTLE, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1, WHSC1-like protein 1, WHSC1L1, pp14328

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

NSD3 inhibition curve using a chemiluminescent assay (#53012). Representative data only; data may vary by lot.

Product Info

Storage and Usage

Citations2

Species

Human

Construct

NSD3 (GST-1021-1322)

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution

Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT, 16 mM glutathione

61 kDa

Amino Acids

1021–1322

Genbank #

NM_023034

UniProt #

Q9BZ95

Tag(s)

N-terminal GST-tag

Background

NSD3 is a histone methyltransferase that preferentially methylates Lys4 and Lys27 of histone H3. Lys4 methylation usually represents a specific tag for epigenetic transcriptional activation, while Lys27 is a mark for transcriptional repression.

References

1. Morishita, M., di Luccio E., Biochim Biophys Acta. 2011 Dec,1816(2):158-63.
2. Rahman, S., et al., Mol Cell Biol. 2011 Jul,31(13):2641-52.

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Datasheets/Protocols

51036 Lot 211018

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NSD3 (1021-1322) (WHSC1L1), GST-tag Recombinant

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