NSC-632839
Catalog #
27709-1
$185
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Description
NSC 632839 hydrochloride is an inhibitor of USP (ubiquitin isopeptidase) activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.
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Synonyms
3,5–Bis[(4–methylphenyl)methylene]–4–piperidone hydrochloride
Product Info
Storage and Usage
Citations
Purity
>98% by HPLC.
Format
Yellow powder
Formula
C21H21NO · HCl
MW
339.9 Da
Solubility
Soluble in DMSO (8 mg/ml)
CAS Registry #
157654-67-6
References
1. Aleo, E. et al. Identification of New Compounds That Trigger Apoptosome-Independent Caspase Activation and Apoptosis. Cancer Res. 2006. 66:9235.
2. Nicholson, B. et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 2008. 17:1035
2. Nicholson, B. et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci. 2008. 17:1035