Mouse basic Fibroblast Growth Factor Recombinant
Catalog #
90112-B
$205
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Synonyms
bFGF, FGF2, Prostatropin, Basic Fibroblast Growth Factor, Fibroblast Growth Factor-2
Product Info
Storage and Usage
Citations
Species
Mouse
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered PBS solution, pH 7.0.
MW
16 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
10–154
Biological Activity
The ED50 was determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Genbank #
P15655
UniProt #
P15655
Background
Basic Fibroblast Growth Factor is found in almost all tissues of mesodermal and neuroectodermal origin and also in tumors derived from these tissues. Endothelial cells produce large amounts of this factor. Some bFGF is associated with the extracellular matrix of the subendothelial cells. Many cells express bFGF only transiently and store it in a biologically inactive form. The mechanism by which the factor is released by the cells is not known. It is released after tissue injuries and during inflammatory processes. FGF receptors are encoded by a gene family consisting of at least four receptor tyrosine kinases that transduce signals important in a variety of developmental and physiological processes related to cell growth and differentiation. bFGF stimulates the growth of fibroblasts, myoblasts, osteoblasts, neuronal cells, endothelial cells, keratinocytes, chondrocytes, and many other cell types.
References
1. Przybylski M. J Wound Care. 2009 Dec,18(12):516-9.
2. Temple S, Qian X. Neuron. 1995 Aug,15(2):249-52.
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