MEG-1 (PTPN4), GST-tag Recombinant
Catalog #
30015
$325
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Description
Recombinant human MEG-1 (also known as PTPN4, protein tyrosine phosphatase non-receptor type 4), encompassing amino acids 637-926 (end). The construct contains an N-terminal GST-tag. The recombinant protein was affinity purified.
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Synonyms
Tyrosine-protein phosphatase non-receptor type 4, Protein-tyrosine phosphatase MEG1, MEG, PTPase-MEG1, PTPN4
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Construct
MEG-1 (GST-637-926(end))
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and 16 mM glutathione
MW
60 kDa
Amino Acids
637-926(end)
Genbank #
NM_002830
UniProt #
P29074
Background
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP acts at junctions between the membrane and the cytoskeleton and has been shown to interact with glutamate receptor delta 2 and epsilon subunits. It also is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
References
1. K. Hironaka, et al., J. Biol.Chem. 2000, 275: 16167-16173
2. M. Gu, et al. Proc. Natl. Acad. Sci. 1996, 93: 12980-12985
2. M. Gu, et al. Proc. Natl. Acad. Sci. 1996, 93: 12980-12985