l-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-lHpyrazolo [3,4-d]pyrimidin-l-yl]-l-piperidinyl]-2-propyn-l-one

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Catalog #

82071

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Bulk/Custom

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Description

l-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-lHpyrazolo[3,4-d]pyrimidin-l-yl]-l-piperidinyl]-2-propyn-l-one, is a derivative of the first-in-class covalent BTK inhibitor ibrutinib. Ibrutinib inhibits B-cell proliferation and survival by irreversibly binding the protein Bruton's tyrosine kinase (BTK). B cell cancers are directly affected by this since the B-cell receptor pathway is often aberrantly active.

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