Human Interleukin-21 Recombinant
Catalog #
90186-A
$130
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Description
Recombinant IL-21 is a disulfide-linked homodimeric protein consisting of 132 amino acid residues, and migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding murine Interleukin-21 mature chain was expressed in E. coli.
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Synonyms
Interleukin 21, IL-21, Za11, IL2
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥97% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered PBS, pH 7.5.
MW
15 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
25–155
Biological Activity
The ED50 was determined by the dose-dependent proliferation of activated B-cells.
Genbank #
Q9HBE4
UniProt #
Q9HBE4
Background
IL-21 stimulates proliferation of B-cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T-cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the NK-cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on NK-cells, T- cells, and B-cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3.
References
1. Pallikkuth, S., et al. Crit Rev Immunol. 2012,32(2):173-95.
2. Spolski, R., Leonard, W.J. Crit Rev Immunol. 2010,30(6):559-70.
3. MacDonald, T.T., et al. Biochem Soc Trans. 2011 Aug,39(4):1061-6.
2. Spolski, R., Leonard, W.J. Crit Rev Immunol. 2010,30(6):559-70.
3. MacDonald, T.T., et al. Biochem Soc Trans. 2011 Aug,39(4):1061-6.
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