Human BAFF-R(CD268) Recombinant

Catalog #

90103-A

$130 *

Size: 10 µg

Qty

Bulk/Custom

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Description

Recombinant human BAFF-R (B cell-activating factor from the TNF family), also known as CD268, is a disulfide-linked monomeric protein consisting of 76 a.a. and migrates as an approximately 9 kDa protein under reducing and non-reducing conditions. Optimized DNA sequence encoding human BAFF-R extracellular domain was expressed in E. coli.

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Synonyms

BAFF-R, B cell-activating factor from the TNF family, CD268

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from a 0.2 µm filtered solution containing 2.5% glycine, 0.5% sucrose, 0.01% Tween-80, 5 mM glutamic acid, pH 4.5.

9 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

1–78

Biological Activity

The ED₅₀ , determined by the ability to block BAFF induced survival of splenocyte cells, was found to be in the range of 1.0-5.0 µg/ml.

Genbank #

Q96RJ3

UniProt #

Q96RJ3

Background

The B cell-activating factor from the TNF family (BAFF), is emerging as an important regulator of B cell and T cell responses. BAFF was originally identified as a factor responsible for B cell survival and maturation .BAFF binds to several receptors. These include transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), BAFF-R (BR3), and B cell maturation Ag (BCMA). BAFF-R appears to be particularly important for the regulation of B cell survival and maturation in the spleen, because A/WySnJ mice expressing a defective BAFF-R have disrupted B cell maturation, similar to that seen in BAFF-deficient mice.

References

1. The effects of BAFF and BAFF-R-fc fusion protein in immune thrombocytopenia. Blood, Dec 2009, 114: 5362 - 5367.
2. c-rel in the regulation of BAFF-R expression in malignant human B cells. Blood (ASH Annual Meeting Abstracts), Nov 2009, 114: 2400.

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Human BAFF-R(CD268) Recombinant

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