FALZ (BPTF), GST-tag Recombinant
Catalog #
31134
$305
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Description
Human Fetal Alzheimer Antigen (FALZ), also known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal GST-tag, MW=41 kDa, expressed in an E. coli cell expression system.
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Synonyms
Fetal Alzheimer Antigen, FALZ, Fetal Alz-50 Clone 1 Protein, bromodomain PHD finger transcription factor, BPTF
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
BPTF/FALZ inhibition curve using a TR-FRET assay (#32632). Representative data only; data may vary by lot.
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
MW
41 kDa
Amino Acids
2791–2911
Genbank #
NM_182641
UniProt #
Q12830
Background
FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
References
1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.
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