Cholesterol-Related

 

PCSK9 is a critical regulator of cholesterol metabolism through its interaction with the hepatic LDL receptor (LDLR). PCSK9 is a kexin (that is,an endopeptidase) found in kidneys, liver, and intestine.  It binds to the EGFR-like domain of LDLR, leading to LDLR degradation. Circulating PCSK9 binds to the extracellular EGF-like domain of LDLR, followed by endocytosis and lysosomal degradation of the PCSK9-LDLR complex. Inhibiting the PCSK9-LDLR interaction is an increasingly desirable drug target for lowering LDL-cholesterol levels because of the great demand for new drugs to replace or supplement statins.  The newly added research tools are invaluable for studying cholesterol metabolism, atherosclerosis, stroke, heart disease, and other diseases related to cardiovascular disorders. Specifically, BPS' PCSK9 neutralizing antibody, useful as a positive control for inhibition. 

BPS Bioscience offers PCSK9 and LDLR proteins, Binding Assay Kits, and PCSK9 Screening/Profiling Services for cholesterol related research. Interested in high throughput screening? Our PCSK9 assay kit is also available in a convenient, homogeneous TR-FRET format. Check this out along with the mutant (D374T) PCSK9 protein and mutant (D374T) PCSK9 assay kit which causes increased affinity of PCSK9 for the LDLR substrate.

Want to advance your project to the next level? Take a look at our PCSK9 Screening and Profiling Services.

19 Item(s)

per page

Catalog#SizeProduct NamePrice
33298 4 ml 3x PCSK9 TR-FRET Assay Buffer
$105
71207 50 µg Anti-PCSK9 Neutralizing Antibody
$490
71216 50 µg Anti-PCSK9 Neutralizing Antibody, Biotin-labeled
$515
71206 20 µg LDLR, Biotin-labeled
$475
71222 50 µg LDLR, FLAG-Avi-Tag (Mouse)
$440
71205 50 µg LDLR, FLAG-tag
$450
71208 20 µg MYLIP/IDOL, His-FLAG-tag
$465
71211 20 µg PCSK9(D374T), Biotin-labeled
$475
72011 384 reactions PCSK9(D374T)-LDLR TR-FRET Assay Kit
$745
71305 50 µg PCSK9, C-terminal Avi-His, Biotin-labeled
$440
71304

50 µg
500 µg

PCSK9, C-terminal His-Avi-tag, Biotin-labeled
Starting at:
$440
71221-1 20 µg PCSK9, His-Avi-Tag (Mouse)
$250
71221-2 50 µg PCSK9, His-Avi-Tag (Mouse)
$440
71220-2 50 µg PCSK9, His-Avi-Tag (Rat)
$440
71220-1 20 µg PCSK9, His-Avi-Tag (Rat)
$250
71204-1 20 µg PCSK9, His-tag
$270
71204-2 50 µg PCSK9, His-tag
$470
72010 384 reactions PCSK9-LDLR TR-FRET Assay Kit
$745
72002 96 reactions PCSK9[Biotinylated]-LDLR Binding Assay Kit
$695

19 Item(s)

per page